Three American brothers who have not spoken to each other in a year set off on a train voyage across India with a plan to find themselves and bond with each other -- to become brothers again like they used to be. Their "spiritual quest", however, veers rapidly off-course (due to events involving over-the-counter pain killers, Indian cough syrup, and pepper spray), and they eventually find...

With a plan to exact revenge on a mythical shark that killed his partner, oceanographer Steve Zissou (Murray) rallies a crew that includes his estranged wife (Huston), a journalist (Blanchett), and a man who may or may not be his son (Wilson).